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"An Assay Platform to Evaluate Cytokine Release & T Cell Activation"

How can we predict the ability of a preclinical drug to inadvertently cause or intentionally inhibit cytokine secretion and T cell activation?

In this white paper, we introduce a services platform designed to predict T cell activation and cytokine release in response to preclinical drugs, and present data based on several known stimulants. Alternatively, this platform’s flexibility lends itself to testing the ability of drugs to inhibit these responses. A better in vitro understanding of immunological regulation will help lead to safer drugs with fewer serious side effects, such as cytokine release syndrome seen with immunomodulatory oncology drugs, as well as more effective anti-inflammatory drugs.

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