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"EHR vs Registry Data for RWE -- Heart Failure as a Case Study"

Electronic health records (EHR) and patient registries are both important sources of real-world evidence -- but which is right for your needs?

Real-world evidence (RWE) is an important component of research, but not all sources of RWE are equally effective, depending on your specific goals and the nature of the evidence you are seeking.

This white paper addresses the differences between two data sources – EHR and patient registries - in terms of:

• Collection and content of RWE for studies of heart failure
• Implications of these differences
• Effects for both for identifying key patient populations for assisting understanding of heart failure management and for potential recruitment for observational research or clinical trials

Once heart failure patients have been identified, many researchers examine the relationship between heart failure and other factors, such as obesity, as measured by body mass index (BMI). As a result, studying and generating real-world evidence (RWE) related to patients with heart failure requires data not commonly found in administrative claims data. In this white paper, we compare and contrast the view of heart failure patients as seen from the perspectives of two large, but distinct, sources of real-world data, both of which contain data points needed for studies of heart failure, such as left ventricular ejection fraction (LVEF) and BMI.

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